BioXpress

The MAb-based drug market is one of the fastest growing categories of the biopharmaceuticals industry. These products are of high value for pharmaceutical industry, both in research as well as drug development activities.

Biosimilar biologics are complex protein structures. The highly experienced BioXpress Therapeutics team has worked on the development of 12 originator MAbs currently on the market. Since Q2 2010, BioXpress Therapeutics has completed the validation of protein sequence, cell line development, analysis of production cell line, and pre-Phase I clinical plans for its first four biosimilar MAbs: adalimumab, bevacizumab, rituximab and trastuzumab.

Each BioXpress Therapeutics monoclonal antibody (MAb) biosimilar drug is developed under strict non-clinical and clinical guidelines as outlined in the European Medicines Agency’s “Guideline on Similar Biological Medicinal Products Containing Monoclonal Antibodies.” Furthermore, each BioXpress Therapeutics biosimilar goes through a complete analytical comparison to determine the product is similar to the innovator product.

To ensure BioXpress Therapeutics has identified the best opportunity within the MAb biosimilar arena, the Company has developed a proprietary database of twenty-five data points for each drug, based on comprehensive analysis of literature and patent databases. All data entry and data analysis is done by the Company’s team, which consists of scientists who have been actively involved in making monoclonal antibody therapeutics since the early 1980s. As a result, the BioXpress scientific team is well versed in the literature and groups who have developed many of the originator MAbs over the decades.

website: www.bioxpress.com

CellNTech

Selexis

Headquartered in Geneva, Switzerland, Selexis SA is a global life science company with technologies for drug discovery, cell line development and scale-up to manufacturing of therapeutic proteins.

Founded in 2001, the Company is dedicated to the development of innovative technologies and world-class expert services that significantly reduce the time, effort, and costs associated with developing high-performance mammalian cell lines for therapeutic protein production (e.g. monoclonal antibodies (MAbs), growth factors, enzymes).

The Selexis SUREtechnology Platform™ improves the way cells are used in the discovery, development and manufacturing of recombinant protein drugs by providing key significant advantages over traditional approaches. The SUREtechnology Platform™ is based on Selexis Genetic Elements™ — novel DNA-based elements that control the dynamic organization of chromatin within all mammalian cells and allow for higher and more stable expression of recombinant proteins. The Selexis SUREtechnology Platform™ provides users a single platform that can be used for a wide range of applications from late R&D to biologics manufacturing including target discovery, cell-based assays, protein production for discovery and pre-clinical studies, diagnostics, bio-manufacturing of therapeutic proteins.

As of 4Q2011, Selexis has generated over 1,300 clonal cell lines being used in a variety of programs from discovery to late-stage clinical trials. More than 20 Selexis cell lines are in clinical trials and the Company anticipates several products manufactured from cell lines using the Selexis SUREtechnology Platform™ to be launched in 2012.

Website: www.selexis.com

Portfolio

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